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This research article examines the transformative impact of modern genomic tools on cassava (Manihot esculenta) improvement, focusing on yield enhancement, nutritional quality, and stress resilience. It discusses the integrated use of high-throughput sequencing, genome editing (CRISPR/Cas9, TALENs), and multi-omics technologies (transcriptomics, proteomics, metabolomics) in breeding programs. These tools enable the precise modification of genes controlling starch biosynthesis, carotenoid accumulation, and disease resistance. The paper also addresses implementation challenges related to technology cost, bioethics, and environmental unpredictability, and emphasizes the potential of AI-assisted genomic analysis and international collaboration to achieve sustainable, data-driven cassava breeding progress.

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