This document aims to share lessons learned from implementing 4.0 technologies on farms/agroindustries based on the experiences of actual cases from the 1st edition of the Agro 4.0 Program. For its elaboration, data surveys were carried out, through forms and interviews, with actors from the projects involved and other specialists in the sector. This Guide is intended for rural producers and agroindustries interested in learning about or improving their processes for adopting 4.0 technologies. Still, it can also help suppliers, startups, innovation ecosystem institutions, government, and participants in other editions of the Program's public notices, among other actors.