The document provides detailed guidance on adopting a multi-sector “One Health” approach to address zoonotic diseases in countries. Published by the Food and Agriculture Organization of the United Nations, the World Organization for Animal Health and the World Health Organization in 2019, this guide aims to facilitate collaboration, communication and coordination between human health sectors. , animal health and the environment to address zoonotic diseases more effectively, efficiently and sustainably. It focuses on several key aspects for the implementation of this approach, including sustainability considerations, establishing multi-sector coordination mechanisms, understanding national context and priorities, and adopting a multi-sector approach for specific technical activities such as strategic planning, emergency preparedness, zoonotic disease surveillance, coordinated research and response, risk assessment, risk reduction, and workforce training.